I wanted to start using grid hotkeys more, but I had this issue that my build order is usually something like 2 cons -> 5 grunts -> 2 cons -> 100 thugs. With gridkeys you could only queue 5 units at once by holding shift. By clicking it's easy to queue 100 units with ctrl-shift-click.

Ctrl-modifier for hotkeys is -1 so that you can remove certain units from queue, but I never use that since it's easier to just drop the whole queue with G hotkey. So I did some work to make the modifier keys configurable and now you can queue 100 units with a single hotkey press if you want. You can find the setting under Control -> Hotkeys ingame.